Fox will be in Stuart Pearce's squad which will play Paraquay at Malaga's La Rosaleda ground.
Kick off is at 8pm UK time or 9pm local time and you can catch the game on Setanta Sports.
Danny Fox in action for City
The friendly is part of England's preparation for this summer's U21 European Championship in Sweden and the former City left back told the FA.com: "Ecuador are going to bring a strong squad with a lot of senior experience. It will be a big learning curve for our players to face opposition from outside Europe and it will be great experience for them ahead of the summer."