Former Coventry City loanee Jack Cork is out for up to eight weeks with an ankle injury.
Cork injured his ankle during Southampton's 1-0 defeat at Arsenal on Wednesday ngiht and Ronald Koeman said to the BBC: "Jack has an ankle ligament injury like he had last season."
Cork is out of contract at St Marys in the summer and Koeman said: "I have spoken to the club and told them I would like to continue with Jack for more seasons and his injury does not change that."