Elliott Ward injured his groin during City's 2-1 defeat at Cardiff on Tuesday night and is likely to be replaced by Marcus Hall who deputised for him for the second half.
Keeper Keiran Westwood has a thumb injury but should be ok to play if not Andy Marshall will step in.
Chris Coleman may also rest one of his strikers. Clinton Morrison,who missed chances at Blackpool and Cardiff, could be the man to be given a rest with Leon Best likely to replace the former Palace striker if the City boss does make change to the front pair.
For Southampton, Stern John is out.
The game kicks off at 5.20pm due to Sky TV.