Warwicks resumed on 7-0 and added fifteen runs before Darren Maddy was caught by Mustard. Thirteen runs later, fellow opener Ian Westwood was bowled by Steve Harmison after making eleven runs.
Ant Botha was next out and when Ateeq Javid was caught by Stokes, Warwicks were 67-4.
Thirty eight runs were added for the fifth wicket which came when Jim Troughton,who had made 41 was caught by Mustard.
Tim Ambrose who had made 31 was trapped lbw by Rushworth and top scorer Rikki Clarke, who hit seven fours in an innings of 68 gave Chris Rushworth his third wicket.
Callum Thorp took the wickets of Carter, Miller and Imran Tahir to give himself a four wicket haul and see Warwicks all out for 224, some 64 runs behind.
Durham were 29-0 after nine overs to lead by 93 runs.