Eddie Niseivc put Nuneaton ahead in the 28 minute before Skipper Gareth Dean added a second in the 37th minute.
Two minutes into the second half, a cracking shot from Justin Marsden gave Kevin Wilkin's side a 3-0 victory in front of a crowd of 211.
Rugby Town ended Hitchin Town's unbeaten twenty six game run with a 2-1 victory. Hamilton put VS ahead in 46th minute but Burke equalised for Hitchin in the 58th minute. In stoppage time, Keane scored a penalty to give Rugby the victory.
Bedworth United, who are looking for a new Chairman following the resignation of David Taylor due to pressures of work, beat Burnham 2-0 with goals from Nadat and Ramsey.
Former Coventry City youngster Arron Stringfellow scored for Daventry Town in a 5-3 win at Beaconsfield Sycob.
In the Midland Alliance, Stratford Town thrashed Willenhall Town 7-0.