The Sky Blues are 11/10 to win the match which kicks off at 5.20pm and is live on Sky TV.
Bet365 are giving odds on Southampton to win of 3-1 with 11/5 on the draw.
The game will see the return of Stern John to the Ricoh Arena. With former City players scoring against the Sky Blues on a regular basis, there is bound to be interest in this bet. If you are planning on taking this bet, get in early to get the best odds.